摘要
目的观察选择性β1-受体阻滞剂美托洛尔对安装永久性人工心脏起搏器的患者的心房、心室起搏阈值和心肌R、P波振幅的影响。方法62例患者中病态窦房结综合征患者30例,高度或Ⅲ度房室传导阻滞患者32例;新安永久起搏器者41例,起搏器更换者21例。安装或更换永久起搏器后1～3d内,静脉注射酒石酸美托洛尔注射液10mg(体重≤60kg)、15mg(体重>60kg),首次静脉注射5mg,5～10min后重复给药。检测静脉注射前及注射后10、30、90、180min心房、心室起搏阈值和心肌P、R波振幅。结果新近安装永久心脏起搏器患者和起搏器更换患者心房起搏阈值、心室起搏阈值在用药前后各时间段均无显著变化(P>0.05);心房P波振幅、心室R波振幅也均无显著变化(P>0.05)。结论静脉注射酒石酸美托洛尔对新近安装永久性人工心脏起搏器患者心房、心室起搏阈值和P、R波振幅无明显影响;对已长期安装永久心脏起搏器患者心房、心室起搏阈值和P、R波振幅也无明显影响。
Objective To observe the effects of metoprolol on the pacing threshold and the amplitude of P and R waves in cardiograph. Methods Sixty-two patients with permanent pacemaker implanted were studied and among them 30 patients had sick sinus syndrome and 32 patients had severe or total AV block. Pacemakers were implanted for the first time in 41 patients and pacemakers replacement were undergone in the other 21 patients. Intravenously metoprolol tartrate （ 10 mg for weight ≤60 kg and 15 mg for weight 〉60 kg） was given to all the patients 1 -3 days after their operation. The pacing threshold and the amplitude of P and R waves on cardiograph were measured before injection and at 10, 30, 90, 180 minutes afterwards. Results No significant changes were oburved in pacing threshold and the amplitade of P and R waves before and after the injection of metoprolol in patients with either newly implanted or replacement of permanent pacemakers. Conclusion Metoprolol tartrate has no effect on atrial and ventricular pacing threshold and the amplitude of P and R waves in patients with permanent pacemakers implantation.
出处
《中国介入心脏病学杂志》
2008年第4期222-224,共3页
Chinese Journal of Interventional Cardiology
