超声联合CA125在预测早期流产中的价值

The value of ultrasonography and CA125 in predicting early abortion

目的探讨卵黄囊的声像图特点及CA125的变化规律在预测早期流产中的价值。方法使用超声对早孕孕妇卵黄囊的形态、大小等特点进行观察,同时采用化学发光法对其CA125水平进行监测。结果难免流产组卵黄囊的测量值与正常早孕组相比,差异有显著性(P<0.05);难免流产组CA125值明显高于正常早孕组及继续妊娠组(P<0.01);且难免流产组卵黄囊大小与CA125值呈负相关(r=-0.695,P<0.05),卵黄囊预测流产的敏感性、特异性分别为80.76%,89.47%;CA125预测流产的敏感性、特异性分别为92.30%,88.89%;两者联合检测预测流产的敏感性、特异性分别为98.51%,79.21%。结论卵黄囊和CA125与早期流产的发生、发展及预后密切相关;联合测定卵黄囊和CA125有助于早期流产的诊断。

Objective To investigate characteristic of gravidas＇ yolk sac and the level of CA125 in early abortion. Methods To observe the characteristic （ morphology, magnitude, etc. ） of yolk sac by transabdominal sonography（TAS）, meanwhile, monitor the level of serum CA125 by chemiluminescent immunoassay （CLIA）of gravidas, Results The size of yolk sac in the inevitable abortion which is clearly different from normal pregnancy（ P 〈0. 05 ） ;The level of serum CA125 of gravidas with inevitable abortion is significantly higher than that of normal and evitable abortion gravidas（ P 〈 0. 01 ） ;It＇ s negative correlation between the size of yolk sac and the level of serum cancer embryo antigen （ r = -0. 695 P 〈 0. 05 ）. The sensitivity and the specificity separately is80. 76% and 89.47% of the YS in predicting EA;The sensitivity and the specificity separately is92. 30% and 88.89% of The CA125 in predicting EA;The sensitivity and the specificity is 98.51% and79. 21% of united the both. Conclusion The YS and CA125 have a close correlation （take place, development and prognosis）with EA;determination the yolk sac and CA125 conduce to diagnosis of early abortion .