维生素D与炎症性肠病的研究进展

Advances in vitamin D and inflammatory bowel disease

由于广泛的免疫调节及抗微生物作用,维生素D与自身免疫疾病的关系受到越来越多的关注.而对于炎症性肠病,尽管根本机制不明,但关于其发病已形成基本共识,即在一定环境因素下,由共生菌及其所产生致炎因子作用于免疫缺陷的个体,产生持续的免疫反应.由于维生素D对固有免疫、适应性免疫的调节作用及其作用方式,以及其可调控上皮细胞抑菌肽的产生,参与肠道微生态的平衡,有理由认为活性维生素D的产生和作用的不足可能参与了炎症性肠病的发病,同时维生素D可能是很有前景的预防和治疗炎症性肠病的药物.

In respect of the comprehensive effect in immunologic regulation （on innate immunity and adaptive immunity） and antibacterial activity, vitamin D is in a high profile position in recent years. Despite the uncertain mechanism, it is a common sense that commensal enteric microbiota initiate and perpetuate immunemediated bowel inflammation. This suggests that there may be a link between vitamin D＇ s function and pathogenesis of inflammatory bowel disease, and vitamin D-associated agents may be prospective for treatment of inflammatory bowel disease.