摘要
乙型肝炎病毒(HBV)感染是目前世界上导致许多慢性肝脏疾病最常见的病因,HBV感染所致的慢性乙型肝炎(chronic hepatitisB,CHB)可以导致肝硬化以及肝细胞肝癌.Kupffer细胞是门脉系统的第一道屏障,也是机体固有免疫系统的重要组成部分,能通过表达TLR、FasL、PD-L1或者产生分泌大量的炎症因子、氧自由基和NO等,作用于HBV感染的肝细胞,在慢性HBV感染的免疫耐受和肝损伤过程中起着重要作用.
Taurine has been characterized as an inhibitor of Kupffer cells which activates a glycine receptor （GlyR） expressing in cell membranes. Activation of the GIyR channel allows the influx of chloride, preventing depolarization of the plasma membrane and the potentiation of excitatory signals in Kupffer cells. Dietary taurine has protective effects in rat models against lipopolysaccharide （LPS）-induced liver injury by inactivating Kupffer cells via actvivating GIyR. LPS leads to an induction of cyclooxygenase-2 and prostanoid formation, which are markedly enhanced during hyperosmotic conditions. It＇s been demonstrated that taurine protects against LPS-induced liver injury in Kupffer cells by inhibiting the hyperosmolarity-induced induction of cyclooxygenase-2 and stimulation of prostaglandin production. Taurine may be useful in clinic for the treatment of LPS-induced liver injury.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第24期2756-2760,共5页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目,No.30471969,No.30772098
