Kupffer细胞在肝癌发生发展中的双向作用

Two-way role of Kupffer cells in the development of hepatoma

随着肿瘤相关巨噬细胞概念的提出,巨噬细胞在肿瘤发生发展中的双向作用已为人们所重视.巨噬细胞除了抗肿瘤作用外,还可通过血管形成、基质重构等机制促进肿瘤的发生发展.作为一类特殊的巨噬细胞,Kupffer细胞在肝癌发生发展中同样起着双向作用.深入研究巨噬细胞特别是Kupffer细胞促进肿瘤发生发展的机制,必将为肿瘤的治疗提供新的靶点.

As the introduction of the concept on tumorassociated macrophages （TAMs）, the two-way role of macrophages in tumor development has been more and more focused. Other than inhibiting the development of tumors as traditional thinking says, macrophages can also promote the proceeding of several kinds of tumors through angiogenesis and matrix remolding, etc. As a special kind of macrophages, Kupffer cells also play a twoway role in the development of liver cancer. The lucubrating of the mechanism of macrophage in the proceeding of tumors must be beneficial to the therapy of tumors.