伐地那非治疗老年糖尿病性勃起功能障碍疗效分析

Vardenafil Significantly Alleviates Erectile Dysfunction in Aged Men with Diabetes

目的:观察伐地那非治疗老年糖尿病(DM)性勃起功能障碍(ED)患者的临床疗效和安全性。方法:选择男性科门诊100例老年ED患者,其中DMED40例,非DMED60例。2组均使用伐地那非,首次剂量20mg,以后维持剂量10mg,1次/周,连续8周。采用国际勃起功能问卷勃起功能评分(IIEF-5)和勃起质量量表问卷(EQS)对患者勃起功能状况进行评估。结果:治疗前后,DMED组患者IIEF-5和EQS评分值分别为(8.1±0.5)分,(18.9±0.2)分(P<0.01);(9.1±1.3)分,(25.1±1.4)分(P<0.01);非DMED组患者评分值分别为(10.1±0.3)分,(21.1±0.2)分(P<0.01),(10.1±1.7)分,(34.2±1.2)分(P<0.01),2组间统计学处理差异有显著性(P<0.05)。DMED组显效17例(42.5%),有效9例(22.5%),总有效率65%。非DMED组显效28例(46.7%),有效16例(26.7%),总有效率73.3%。DMED和非DMED2组间统计学处理差异有显著性(P<0.05)。结论:伐地那非治疗能显著改善老年DMED患者的勃起能力,提高生活质量。

Objective： To observe the efficacy and safety of vardenafil in the treatment of erectile dysfunction （ED） in aged men with diabetes mellitus （ DM ）. Methods, One hundred outpatients with diagnosed ED （40 diabetic and 60 non-diabetic） received vardenafil at the initial dose of 20 mg and sustained dose of 10 mg once a week for 8 weeks, and their erectile functions were evaluated by IIEF and EQS. Results ： The scores on IIEF and EQS in the diabetic ED group were 18.9 ± 0.2 and 25.1 ± 1.4 after the vardenafil treatment, siginifcantly higher than 8.1 ± 0.5 and 9.1 ± 1.3 before the treatment （P 〈0.01 ） , and the non -diabetic group scored 21.1 ±0.2 and 34.2 ± 1.2 on IIEF and EQS after the treatment, as compared with the statistically lower scores of 10.1 ± 0.3 and 10.1 ± 1.7 before it （P〈0.01）. The total rate of effectiveness was 65% in the diabetic and 73.30% in the non-diabetic group, with statistical differences （ P 〈 0. 05 ）. Conclusion ： Vardenafil can significantly improve erectile function and is well tolerated in the aged males with diabetic ED.