摘要
阿司匹林抵抗的可能原因包括低依从性、药物交叉反应、药物剂量不足、血小板周转加快、相关基因多态性以及血栓素非经血小板旁路途径形成等。现有的针对阿司匹林抵抗的实验室方法包括对TXA2及其代谢产物的检测和血小板功能的测定,临床上应采取措施减少阿司匹林抵抗以取得理想的预防和治疗效果。
Possible causes of aspirin resistance include poor compliance, drug interaction, inadequate aspirin dose, increase turnover of platelets, genetic polymorphisms of cyclooxygenase-1, and upregulation Of alternate （non-platelet） pathways of thromboxane prodution. Laboratory methods used to detect aspirin resistance include those that measure thromboxane A2 production and platelet function. Clinical measure should be taken to reduce aspirin resistance in order to get perfect prevention and curative effect.
出处
《国际内科学杂志》
CAS
2008年第8期481-484,共4页
International Journal of Internal Medicine
关键词
阿司匹林抵抗
血小板功能
基因多态性
Aspirin resistance
Platlet function
Genetic polymorphisms
