连术颗粒治疗急性感染性腹泻216例

Clinical study of Lian-shu granule in treatment of 216 patients with acute infectious diarrhea

目的观察连术颗粒治疗急性感染性腹泻的临床疗效和安全性。方法采用多中心随机双盲对照试验。临床病例分为两组,连术组216例,口服连术颗粒制剂5 g,每日2次;对照组78例,口服黄连素片,0.2 g,每日3次。疗程3 d。结果连术颗粒治疗急性腹泻有效率为97.22%(210/216),对照药黄连素片为87.18%(68/78)。两药疗效间差异有显著性(P<0.01);试验组中医症状积分疗效优于对照组(P<0.01);试验组患者大便白细胞镜检转阴方面优于对照组(P<0.01)。结论连术颗粒是治疗急性腹泻的安全有效的中药制剂。

Objective To observe the efficacy and safety of Lian-shu granule in treatment of acute diarrhea. Methods A randomized, double-blind, multi-center controlled trials were adopted in this study. Two hundred and ninety-four patients were divided into two groups. Two hundred and sixteen patients in Lian-shu group were received 5 g Lian-shu granule twice daily while 78 patients in control group were received 0. 2 g Berberine tablet three times daily for 3 d continuously. Results The effective rate for treatment of acute diarrhea in Lian-shu group was 97.22 % （210/216 ）, and was 87.18 % （68/78）in control group, the difference being significant（ P 〈 0.01 ）. The curative effect based on symptom accumulation score and the number of white blood cell （WBC） in stool were also observed showing that Lian-shu granule are better（ P 〈 0.01 ）. Conclusion Lian-shu granule is an effective and safety agent in treatment of acute infectious diarrhea.