皮肤型孢子丝菌病316例临床分析

Clinical analysis of 316 cases of cutaneous sporotrichosis

目的探讨孢子丝菌病的临床特征及病理特点,指导临床实践。方法分析1972～2007年间就诊于我院的孢子丝菌病447例,其中有详细资料者316例,做皮肤组织病理检查的203例中,105例做了PAS染色检查。结果春季发病者占50.34%,临床分型以固定型略多(52.53%)。儿童主要以面部发病。主要病理改变为混合细胞性肉芽肿。PAS染色阳性率为38.1%。结论孢子丝菌病常年皆可发病,近几年有增多的趋势,春季为本病高发季节。儿童皮损主要在面部,多为固定型。病理改变多为混合细胞性肉芽肿。病理切片、PAS染色诊断阳性率不高,确诊主要靠真菌培养。

Objective To investigate the clinical and histopathological characters of sporotrichosis. Methods In this study included 447 cases of Sporotriehosis which were diagnosed by clinical manifestations and mycological culture during 1972 - 2007. Detailed information were obtained from 316 cases. Results of histopathologieal examination and PAS staining were obtained from 203 and 105 cases respectively. Results There were 50.34% patients who fell ill in spring. Patients who presented with the fixed cutaneous form accounted for 52.53% , which were a little more than those who presented the lymphangitic cutaneous form. The lesions were mostly on the face in children. The main manifestations of histopathology were inflammatory granuloma,with mixed cellular granuloma to a greater degree. The positive rate of PAS staining was 38.1%. Conclusion The cases of sporotrichosis are increasing recently and spring may be the season with high incidence. The lesion in children is mostly on the face, and frequently presented as fixed cutaneous sporotrichosis. The main manifestations of histopathology were inflammatory granuloma,with mixed cellular granuloma to a greater degree. Mycological culture is the gold standard for diagnoses.