布地奈德对支气管哮喘豚鼠神经生长因子表达和白细胞介素-1β水平的影响

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摘要支气管哮喘（以下简称哮喘）是一种由多种细胞和细胞因子参与发挥作用的气道炎症性疾病，其发病机制目前尚未完全明确。有研究显示，神经生长因子（NGF）作为神经系统和免疫系统的桥梁参与了哮喘发病的气道炎症过程。肺泡巨噬细胞（AMs）广泛分布于支气管-肺泡表面，是许多免疫及炎症反应的始动环节。目前发现在AMs中有NGF表达，且激活的AMs是IL-1β的主要来源。糖皮质激素（以下简称激素）是目前治疗哮喘行之有效的药物之一，它可作用于哮喘发病的多个环节。本研究旨在观察哮喘豚鼠AMs中NGF蛋白表达及支气管肺泡灌洗液（BALF）中IL-1β水平的变化，及激素对其的影响。

作者李丽孔灵菲王亚婷仲昭双

机构地区中国医科大学附属第一医院呼吸疾病研究所

出处《中华内科杂志》 CAS CSCD 北大核心 2008年第9期764-765,共2页 Chinese Journal of Internal Medicine

基金辽宁省教育厅高等学校科学技术研究项目（2004D188）

关键词 IL-1Β水平神经生长因子支气管哮喘哮喘豚鼠白细胞介素-1Β 因子表达布地奈德支气管肺泡灌洗液

分类号 R686 [医药卫生—骨科学]

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