妊娠期肝内胆汁淤积症实验室指标生物参考区间的建立及临床意义的探讨

To discuss the setting up and clinical meaning of the of laboratory indexs on intrahepatic cholestasis of pregnancy

目的:探讨妊娠期肝内胆汁淤积症实验室指标的生物参考区间及临床意义。方法:筛选506例正常妊娠者及358例妊娠期肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy,ICP)患者,分别测定妊娠期肝内胆汁淤积症实验室指标TBA、TB、DB、CG,并将506例正常妊娠者按孕龄,358例ICP患者按疾病轻重度分组进行比较。结果:506例正常妊娠者TBA、TB、DB、CG含量与孕龄无关,其生物参考区间分别为TBA:0～15.29μmol/L,TB3.86～17.90μmol/L,DB0.61～4.81μmol/L,CG0～5.46mg/L。ICP患者TBA、TB、DB、CG含量与正常妊娠比较有显著差异(P<0.05),轻度组与重度组比较也有显著差异(P<0.05)。结论:妊娠期肝内胆汁淤积症实验室指标的生物参考区间的确立对临床辅助诊断ICP具有重要意义,而ICP患者TBA、TB、DB、CG含量测定可作为ICP临床分度诊断的依据,有助于疾病病情判断。

Objective：To investigate the biologic reference interval and clinical meaning of laboratory indexs on intrahepatic cholestasis of pregnancy. Methods：506 normal pregnancy women and 358 intrahepatic cholestasis of pregnancy women（ICP） was elected, detected the laboratory indexs of intrahepatic cholestasis of pregnancy：TBA,TB,DB,CG respectlvely,and 506 normal pregnancy women based on gestational age ware compared,358 ICP women based on the serious degree of the condition ware compared. Results：the content of TBA,TB,DB,CG wasn＇t related to gestational age in 506 normal control group,and the biologic reference interval are： TBA,TB,DB,CG,There are obviously difference of the content of TBA,TB,DB,CG between the ICP women and the normal control group （P〈0,05）, there are significant difference between the mild group and the severe group too. Conclusion：There is an important meaning to setting up the biologic reference interval of laboratory indexs for diagnosing ICP clinically, According to detect the content of TBA,TB,DB,CG we can divide clinical grading on ICP,and can help to judge the disease,