百令胶囊联用复方α-酮酸对腹膜透析患者微炎症的影响

Influence of Microinflamation on Patients with Peritoneal Dialysis by Bailing Capsule Combined with Compound α-Ketoacid

目的:探讨百令胶囊联用复方α-酮酸对维持性腹膜透析患者微炎症状态的影响。方法:选择在本院血液净化中心维持腹膜透析6个月以上的患者119名,首先按照不同的原发病将患者分层,再将同一原发病患者随机分至治疗组和对照组,治疗组患者62名,对照组患者57名;两组患者分别在开始观察时、1个月、3个月时测定超敏C反应蛋白(Hs-CRP)和白介素6(IL-6)水平,治疗组患者连续应用百令和复方α-酮酸三个月,对照组应用安慰剂治疗3个月。结果:治疗组患者在治疗后HS-CRP及IL-6的水平均较治疗前明显下降,差异有统计学意义(P<0.01)。结论:百令胶囊和复方α-酮酸联合应用可以有效控制腹膜透析患者的微炎症状态。

Objective： To access the influence of microinflamation on patients with maintenance peritoneal dialysis who were treated by Bailing capsule combined with compound α-ketoacid. Method： One hundred and nineteen patients with peritoneal dialysis were treated for more than 6 months were divided into different groups according to the primary diseases, then the patients with the same disease were randomly divided into treatment group and control group. There were 62 patients in treatment group and 57 patients in control group. The Hs-CRP and IL-6 were examined on two groups at the beginning, one month and three months,Result： The average level of Hs-CRP and IL-6 were decreased significantly after treatment. The difference was significant （ P 〈 0.01 ）. Conclusion ： The combined application of Bailing capsule and Co. α-ketoacid can effectively control the microinflamation in patients with maintenance peritoneal dialysis.