乳酸菌素根除治疗幽门螺杆菌感染的临床研究

Study of Lactobacillinn on Eradication the Helicobacter Pylori Infection

目的:探讨乳酸菌素在幽门螺杆菌(Hp)感染根除治疗中的作用。方法:66例慢性糜烂性胃炎、萎缩性胃炎、消化性溃疡、胃镜胃窦部快速尿素酶试验(RUT),^(14)C-尿素呼气试验(^(14)C-UBT)均阳性的患者随机分为两组:试验组36例。应用乳酸菌素、雷贝拉唑、克拉霉素、阿莫西林,口服7d。对照组30例,应用雷贝拉唑、克拉霉素、阿莫西林。服7 d。结果:4周后复查胃镜RUT及^(14)C-UBT,两者均阴性,试验组31例(86.1%),明显高于对照组19例(63.3%)。两组比较有统计学差异(P<0.05)。副作用发生率,试验组2例(5.5%),对照组10例(33.3%),后者明显高于前者(P<0.01)。结论:在雷贝拉唑加阿莫西林、克拉霉素标准三联疗法基础上加用乳酸菌素,可以明显提高Hp根除率。

Objective： To study the efficacy of Lacidophilin on eradication the Helicobacter pylori（Hp） infection. Method： The ^14 C-urea breath test（^14C-UBT） and rapid urease test（RUT） were examined by gastroscopy with Hp positive outcome in 66 patients with peptic ulcer,chronic cerosive gastriitis and atrophic gastritis were randomly divided into two groups. Thirty-six patients in test group were treated by Lacidophilin, Rabeprazole Amoxicillin and Clarithromycin;Thirty patients in control group were treated by Rabeprazole, Amoxicillin, and Clarithromycin. The course of treatment was 7 days. Result： After 4 weeks,Hp was examined by ^14C-UBT and RUT. Hp were 31 subjects eradicated in the test group and 19 cases eradicated in the control group. The eradication rate（86.1% ） of test group was higher than that （63.3%） of control group（P 〈0.05 ）. The side-effect was 2 patients（5.5% ） in test group, 10 patients （33.3%） in control group （P 〈 0.01 ）. Conclusion： Lacidophilin, Rabeprazole, Amoxicillin and Clarithromycin on eradicate Hp is better than that Rabeprazole, Amoxicillin and Clarithromycin triple therapy.