丹皮酚聚乳酸微球的制备及药剂学性质

Preparetion and characteristics of paeonolum polylactic acid microspheres

目的:制备丹皮酚聚乳酸微球,并考察其药剂学性质。方法:采用乳化溶剂挥发法制备丹皮酚聚乳酸微球,用光学显微镜考察微球的粒径,用扫描电镜观察微球的形状和表面形态,用差示扫描量热法研究药物在载体中的分散状态及相互作用。结果:所制得的丹皮酚聚乳酸微球外形圆整,平均粒径为(23.25±0.15)μm(n=300),载药量为(11.4±0.5)%(n=3),药物包封率为(63.8±1.6)%(n=3),24h体外累计释药量44.63%。结论:丹皮酚聚乳酸微球制备工艺稳定,具有良好的缓控释能力。

OBJECTIVE To characterize the paeonolum polylactic acid microspheres newly prepared. METHODS Paeonolum polylactic acid microspheres were prepared by emulsifying solvent-evaporation process. The particle size and shape were examined by optical microscope; the morphology was observed by scanning electron microscope; the dispersion status of paeonolum and interactions between paeonolum and carriers were studied using DSC. RESULTS The micropheres were round and its surface was smooth. Arithmetic mean diameter was （23.25 ± 0. 15）μm（n = 300）, load efficiency was （11.4 ±0. 5） % （n = 3）, encapsulation rate was （63.8 ± 1.6）% （n = 3）, and the accumulative release percentage was 44.63% in 24 hours. CONCLUSION The technology of preparation was successful and paeonolum polylactic acid microspheres exhibite good sustained-release capacity.