卡前列素氨丁三醇对产后出血高危因素的应用时机及效果探讨

The investigation in application time and effect of carboprost in severe postpartum hemorrhage

目的:探讨卡前列素氨丁三醇对有产后出血的高危因素患者应用时机及效果。方法:对100例有引起产后出血高危因素患者随机分为两组,研究组直接给予卡前列素氨丁三醇预防性治疗;对照组胎儿娩出后经按摩子宫、使用缩宫素、卡孕栓等物理和化学方法治疗无效或15min出血量超过500mL者,再给予卡前列素氨丁三醇治疗,观察两组间不同时间出血量的差异。结果:研究组中不同时间的出血量明显少于对照组,且产后大出血的发生率明显低于对照组,差异均具有统计学意义。结论:对有产后出血的高危因素患者预防性使用卡前列素氨丁三醇比常规处理方法无效时再使用的效果更好,进一步降低了产后大出血的发生率。

OBJECTIVE To investigate the application time and effect of carboprost in severe postpartum hemorrhage. METHODS 100 patients with high risk to postpartum hemorrhage were randomly divided into two groups. The study group was given with preventive treatment by carboprost. The control group were given with chemical and physical treatment, such as kneading the uterus,oxytocin or methyl carboprost suppositories first, carboprost was used 15 minutes after fetal disengagement if the amount of bleeding was over 500 mL. Observe the difference of amount of bleeding during different time between the two groups. RESULTS The amount of bleeding in study group of different time was obviously less than the control group. The incidence rate of severe postpartum hemorrhage was much lower in study group. The differences were of statistical significance. CONCLUSION The preventive use of carboprost in patients with high risk to postpartum hemorrhage attained much better effects, and depressed the incidence rate of severe postpartum hemorrhage.