期刊文献+

一种新的药物传递系统——超声微泡剂 被引量:2

下载PDF
导出
摘要 目的:探讨超声微泡剂作为药物载体传输药物的机制及临床应用前景。方法:查阅国内外文献,进行归纳总结,分析其作用机制及应用前景。结果:超声微泡剂可作为药物载体,可传输基因和药物,能提高基因的转染率和表达,配合超声处理产生的空化效应可提高细胞膜的通透性,利于药物穿透;并且具有靶向性。因此在基因治疗和抗肿瘤治疗方面有很好的应用前景。结论:随着超声技术和微泡剂制备技术的发展,超声微泡剂必将为临床治疗提供一种安全、高效、无创的超声介导靶向传输及治疗系统。
出处 《中国医院药学杂志》 CAS CSCD 北大核心 2008年第13期1110-1112,共3页 Chinese Journal of Hospital Pharmacy
  • 相关文献

参考文献14

  • 1牛海燕,智光.超声造影剂的研究进展[J].中华医学超声杂志(电子版),2006,3(6):368-370. 被引量:9
  • 2晏春根,夏国园.超声微泡造影剂与靶向治疗[J].现代实用医学,2005,17(11):723-725. 被引量:3
  • 3谭开彬,高云华,刘平,刘政,杨莉,左松.机械振荡法制备脂膜超声造影剂的初步实验研究[J].中国超声医学杂志,2006,22(8):561-563. 被引量:14
  • 4Maruyama H, Matsutani S, Saisho H, et al. Different behaviors ofmi2 crobubbles in the liver: time-related quantitative analysis of two ultrasound contrast agents, levovist and definity [J]. Ultrasound Med Biol, 2004, 30 (8) : 1035-1040.
  • 5Gotoh K,Umeshita K, Endoh M, et al. Ultrasound - mediated nonviral ex vivo genetransfer into liver graft[J] . Transplantation ,2004 ,78(2) :616-617.
  • 6Miao CH, Brayman AA, Loeb KR, et al. Ultrasound enhances gene delivery of human factor IX plasmid [J]. Hum Gene Ther, 2005, 16(7) : 893-905.
  • 7Pitt WG, Husseini GA, Staples BJ. Ultrasonic drug delivery- a general review[J]. Expert Opin Drug Deliv, 2004,1 ( 1 ) : 37-56.
  • 8Luo H, Fishbein MC, Berglund H, et al. Comparison of intravascular ultrasound measurements at the sites of balloon dilatations of femoral arterieswith measurements of postmortem gross arterial segments at the same sites[J]. Am J Cardiol, 1997, 79 (11):1564-1567.
  • 9Porter TR, Xie F. Therapeutic ultrasound for gene delivery [J]. Echocardiography, 2001, 18 (4):349-353.
  • 10郑元义,王志刚,冉海涛,张群霞,李晓东,凌智瑜,卢岷,任红.诊断超声加微泡造影剂对新生血管的作用[J].中国医学影像技术,2004,20(3):349-351. 被引量:22

二级参考文献53

共引文献71

同被引文献19

  • 1谭开彬,高云华,刘平,刘政,杨莉,左松.机械振荡法制备脂膜超声造影剂的初步实验研究[J].中国超声医学杂志,2006,22(8):561-563. 被引量:14
  • 2梅林,孙洪范,宋存先.紫杉醇制剂研究进展[J].中国药学杂志,2006,41(18):1366-1370. 被引量:16
  • 3王巍,张秋禹,张和鹏,李丽君,罗绍兵.医学造影用微泡材料制备方法研究进展[J].材料导报,2007,21(10):47-50. 被引量:5
  • 4Skinner M. Therapy: Drugs hitch a ride[J]. Nature Rev Cancer, 2010, 10: 384-385.
  • 5Gels NA, Katus HA, Bekeredjian R. Microhubhles as a vehi- cle for gene and drug delivery: current clinical implications and future perspectives[J]. Curr Pharm Des, 2012, 18 ( 15 ) : 2166- 2183.
  • 6Sboros V. Response of contrast agents to ultrasound[J]. Adv Drug Del Rev, 2008, 61)(10) : 1117-1136.
  • 7Kheirolomoom A, Dayton PA, active microbuhbles conjugated Lum AF, et al. Acoustically- to liposomes: characterization of a proposed drug delivery vehicle[J].J Controll Rel, 2007, 118 : 275-284.
  • 8Sugahara KN, Teesalu T, Karmali PP, et al. Coadministra tion of a tumor-penetrating peptide enhances the efficacy of cancer drugs[J]. Science, 2010, 328(5981): 1031-1035.
  • 9Yan F, Li L, Deng ZT, et al. Paclitaxel-liposome microbub- ble complexes as ultrasound-triggered therapeutic drug delivery carriers[J].J Controll Rel,2013, 166(3) : 246-255.
  • 10Klibanov AL,Shevchenko TI, Raju BI, et al. Ultrasound-trig- gered release of materials entrapped in microbubble-liposome constructs: a tool for targeted drug delivery[J]. J Controll Rel, 2010, 148:13-17.

引证文献2

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部