不稳定心绞痛患者高浓度阿魏酸钠静脉滴注发生持续心绞痛

Persistent angina pectoris following intravenous infusion of high-concentration sodium ferulate in a patient with unstable angina pectoris

1例64岁男性因患冠心病伴不稳定心绞痛住院治疗。住院第3天,给予阿魏酸钠0.6 g+5%葡萄糖注射液250 ml静脉滴注,滴速3 ml/min。滴注约30 ml后患者发生持续心绞痛,面色苍白,乏力,BP 80/50 mmHg,心电图呈心肌缺血性改变。患者在停药,吸氧,平卧休息后好转,心肌酶谱均在正常范围,排除急性心肌梗死,因此考虑为阿魏酸钠诱发心绞痛。

A 64-year-old man was hospitalized with coronary heart disease accompanied by unstable angina pectoris. On hospital day 3, he was infused with sodium ferulate 0.6 g dissolved in 250 ml of glucose 5% at a rate of 3 ml/min. After receiving about 30 ml of the infusion, the man developed persistent angina pectoris, pale face, and fatigue. His BP was 80/50 mmHg; his ECG showed myocardial ischemic change. Sodium fenAate was discontinued. His condition improved after the patient was given with oxygen therapy and placed in the horizontal position. His myocardium enzymogram was within normal ranges. Acute myocardial infarction was excluded. And his angina pectoris was considered to be related to sodium ferulate.