氨基酰-tRNA合成酶编校相关的生理、病理效应和药物设计

Physiology,pathology and drug design related with editing of aminoacyl-tRNA synthetase

氨基酰-tRNA合成酶(aaRS)催化tRNA的氨基酰化反应,为生物体内蛋白质合成提供原料。许多aaRS为保持蛋白质翻译的精确性,在进化的选择压力下产生了编校功能。近年来,人们越来越多关注aaRS编校功能同人类健康之间的关系。在过去的几年中,对于aaRS编校功能缺陷在细胞内的生理效应,与疾病发生的关系和以编校活性位点作为药靶设计、开发新型抗生素的研究中取得了重要的进展。

Aminoacyl-tRNA synthetases （aaRSs） catalyse aminoacylation of their cognate tRNAs for protein biosynthesis. Many aaRSs developed editing function under the stress of evolutionary selection for translation fidelity. Recently, the investigators pay more attention to the relation between the editing function and human health. Here, a few impressive progresses in understanding the cell physiology, pathology and drug design related with editing function of aminoacyl-tRNA synthetase were reviewed.