药效学相互作用的定量计算方法与模拟研究

Quantitative approach for calculation of pharmacodynamic interactions and simulation of combined response

目的:建立一种药效学相互作用的定量计算方法和模拟方法,用以分析复方的配伍规律。方法:根据复方的组分数,采用相应的正交设计;1水平为"高剂量,"2水平为"低剂量"。并用一个实例对此模型进行了考证;模拟偏倚由两种散点图结合评价。结果:本法可计算各组分不同剂量水平对复方药效贡献大小,从而确定最佳的组方;还可分析各配伍组的相互作用性质和交互效应;采用的复方效应模型,可对不同剂量水平组合的复方进行药效模拟,由散点图来评价预测的准确程度。结论:本法将定量分析方法和计算机模拟相结合,具有可行性,能为同类研究和二次文献分析等提供一个新的方法。

Objeetive： An approach is set up to calculate pharmacodynamic interaction and simulate the combined response. Method： An orthogonal design with 1-level = high dose and 2-level = low dose was adopted. An example of the compound with four components was applied to evaluate this quantitative approach. The bias was evaluated by the both scatter plots. Result： This approach can calculate the value of each component with different dose by its contribution to combined response, and the value is related to the importance of a compound. Drug interactions were evaluated among the combinations in each group. The prediction model performed well and simulated the combined response in the different of components in combination. Conclusion ： The approach can be used in the similar research, and it also provides predictions of component combinations from the other studies by simulation.