丹桂活血止痛颗粒的镇痛、抗炎及抗软组织损伤作用

Effect of Dangui Huoxue Zhitong Granule on Analgesia,Anti-inflammation and Anti-injury of Soft Tissues

目的观察丹桂活血止痛颗粒的镇痛、抗炎和抗软组织损伤效果。方法采用炎症、疼痛及软组织损伤动物模型,观察丹桂活血止痛颗粒作用后小鼠腹腔注射醋酸引起的扭体反应次数、小鼠热板法的痛阈值、小鼠耳肿胀、大鼠足跖肿胀情况。结果丹桂活血止痛颗粒能够显著降低小鼠腹腔注射醋酸引起的扭体反应次数、明显提高小鼠热板法的痛阈值(P<0.05);能够显著减轻小鼠耳肿胀、大鼠足跖肿胀,抑制醋酸引起的小鼠腹腔毛细血管通透性增加(P<0.05);可显著改善大鼠软组织损伤模型伤肢肿胀程度,减轻肌肉组织瘀血、肿胀(P<0.05)。结论丹桂活血止痛颗粒具有显著的镇痛、抗炎和抗软组织损伤的作用。

Objective To observe the effect of Dangui Huoxue Zhitong Granule （Granule of Radix Salviae Miltiorrhizae and Ramulus Cinnamomi for activating blood circulation to stop pain） on pain, inflammation and injury of soft tissues. Methods Animal models of inflammation, pain and traumatic injury of soft tissues were adopted for observing the twisting reaction after iniraperitoneal injection of acetic acid, pain threshold of hot-plate test, auricular selling of mice and metatarsal swelling of rats. Results Dangui Huoxue Zhitong Granule could decrease conspicuously the twisting reactions, increase the pain threshold （P〈0.05）, relieve the auricular selling of mice and the metatarsal swelling of rats, inhibit the mice abdominal capillary hyperpermeability caused by acetic acid （P〈0.05）, and relieve the swelling of involved limbs, blood stasis and swelling of muscles of rats with soft tissue injury （P〈0.05）. Conclusion Dangui Huoxue Zhitong Granule is effective in analgesia, anti-inflammation and antiqnjury of soft tissues.