540株铜绿假单胞菌12年耐药情况分析

Analysis of Drug Resistance of 540 Strain Pseudomonas aeruginosa in the Past 12 Years

目的:分析导致临床感染的540株铜绿假单胞菌的临床特点及耐药情况,为临床预防感染及合理用药提供依据。方法:回顾性分析12年来540株铜绿假单胞菌的耐药情况。结果:住院患者铜绿假单胞菌检出率明显高于门诊患者,且以重症病房(ICU)尤为显著;下呼吸道感染是主要的临床感染来源;中老年人及慢性病患者,重症患者为易被侵袭人群;铜绿假单胞菌对多数抗生素有较高的耐药性及多重耐药性,且耐药性有逐年上升的趋势。结论:铜绿假单胞菌是临床常见条件致病菌,耐药性严重。治疗中应根据分离株耐药特点选择合理用药方案,避免多重耐药铜绿假单胞菌的出现。

Objective： To analyze the clinical features and the drug resistance of 540 strain Pseudomonas aeruginosa （PA） which caused clinical infection,and offer basis for the prevention of clinical infection and the reasonable use of drugs. Methods：540 strain Pseudomonas aeruginosa from 1995 to 2006 were analyzed retrospectively, Results.. The detectable rate of inpatients Were greater than outpatients,above all,ICU detectable rate was the highest.The main clinical infection source of PA was the respiratory infection. Aged people,those who suffered from chronic diseases and the severely ill were easily infected. There was a high ratio of drug resistance or multi-drug resistance for PA to most antibiotics,and the ratio was rising. Conclusion：The infection caused by PA was common in hospital. The problem of drug resistance was very serious. Antimicrobial agents should be chosen according to the results of antimicrobial susceptibility. It was important to avoid multi-drug resistant Pseudomon aeruginosa（MDRP）.