摘要
犬由股动脉放血，维持血压（５．３３～６．６７）ｋＰａ９０ｍｉｎ，在休克期静脉输入地尔硫艹卓０．６ｍｇ／ｋｇ，再进行休克复苏，并观察１５０ｍｉｎ。结果表明：地尔硫艹卓具有提高ＭＡＰ，改善心肌收缩性；降低心肌脂质过氧化产物丙二醛（ＭＤＡ）含量，提高心肌超氧化物歧化酶（ＳＯＤ）活力的作用；对心肌超微结构有明显的保护作用。
Canines were bled rapidly to a blood pressure of (5.33～6.67) kPa((40～50)mmHg) and maintained at that level for 90 min.At 30 min into hemorrhagic shock,canines received either saline or diltiazem(0.6mg/kg,iv)as treatment.The results showed that diltiazem treatment could significantly increase MAP,dp/dtmax and decrease MDA,increase SOD of heart.Electron microscope data suggest that diltiazem has a protective effect in myocardial structure.
基金
冶金工业部有偿资助
