幕上神经外胚叶肿瘤临床分析(附4例临床报告及文献复习)

Clinical analysis of supratentorial primitive neuroectodermal tumors(4 cases clinic report and review of the literatures)

目的探讨幕上神经外胚叶肿瘤的临床特点及治疗方法。方法对我院2005年1月～2007年1月收治的4例幕上神经外胚叶肿瘤的临床资料进行回顾性分析。结果4例患者1例位于顶叶，1例位于丘脑，1例位于额叶，1例位于双额叶及胼胝体。CT显示为高或等密度影，增强后可强化。MRI为长T1长T2信号，或混杂信号，增强后可强化。2例在显微镜下全切，1例次全切，1例部分切除。病理诊断为原始神经外胚叶肿瘤。术后行放化疗，术后3个月～10个月复发。结论幕上原始神经外胚叶肿瘤为高度恶性肿瘤，愈后差，手术后应行放化疗。

Objective To explore the diagnosis and treatment of supratentorial primitive neuroectodermal tumor（ SP-NET）. Methods Four cases with primitive neuroectodermal tumor were retrospectively reviewed from January 2005 to January 2007. Results One case was located in parietal lobe and one, frontal lobe, one thalamencephalon, one double frontal lobes and corpus callosum, Tumors were hyperintense or isointense on CT. Postcontrast CT showed a moderate enhancement in the mass, On MRI imaging, the tumors showed heterogeneous signal intensity in both T1-and T2-weighted images. On contrast-enhanced,the mass showed enhancement in all cases. Two cases were totally reseeted by microsurgical technique, one case was subtotally reseeted, one ease was partly reseeted. All tumors were diagnosed according to pathological examination and received postoperative irradiation and chemotherapy. All tumors relapsed between 3 to 10 months after therapy. Conclusions SPNET is malignant tumor,The prognosis is bad. The patients should receive operation,postoperative irradiation and chemotherapy.