树突状细胞亚群与重症肌无力

Dendritic cell subsets and myasthenia gravis

重症肌无力（MG）是一种依赖T细胞的抗体介导的以神经肌肉接头处传递障碍为特征的自身免疫性疾病，与机体免疫调节失衡有关。树突状细胞（DC）是目前功能最强的抗原递呈细胞（APC），在调节机体免疫反应中起着重要作用。不同表型的DC在自身免疫性疾病中的作用不同，它们通过不同的途径参与MG的发病。DC分泌的细胞因子在MG发病机制中也起着重要作用。细胞因子干预诱导的耐受性DC在治疗MG中取得了巨大进步，有望成为治疗MG的一种新方法。

Myasthenia gravis （MG） is a T-cell-dependent and antibody-mediated autoimmune disease of the neuromuscular junction, which may be associated with imbalance of immunomodulation. Dendritic cells （ DC ） are highly specialized antigen, presenting cells playing critical roles as instigators and regulators of immune responses. These DC can be either primary effector T cells or activated regulatory T cells depending on the function of the DC or perhaps distinct DC subsets. Cytokine network secreted by DC may be of importance in the pathogenesis of MG. Several strategies to engineer these cells are emerging because the subset and functional stage of DC appear to be critical for tolerance induction. DC therapy may be a new approach in the treatment of MG.