系统血液快速固有免疫反应

Systemic hematogenic quick innate immunoreaction

在人血循环中存在对抗致病原的系统血液快速固有免疫反应，在血浆中致病原能激活红细胞调控白细胞分泌IL-8。致病原在血浆中可被补体系统识别，绝大多数附有补体C3b致病原被红细胞粘附，递呈给血小板和白细胞，可引发血浆补体固有免疫反应、红细胞固有免疫反应、血小板固有免疫反应、白细胞固有免疫反应和淋巴细胞适应免疫反应。在体外，用仿真自然实验体系探讨抗致病原（酵母菌或肿瘤细胞等）系统血液快速固有免疫反应，其结果显示在系统血液免疫反应中存在一个红细胞固有免疫反应主干道，补体与红细胞补体受体Ⅰ型（CR1或CD35）在系统血液快速固有免疫反应中扮演着极重要的角色。

There is systemic hematogenic quick innate immunoreaction against pathogen in human blood circulation. Pathogen could activate red blood cell to modulate IL-8 release from white blood cells in plasma. Pathogens are recognized by complement in plasma. Most pathogens adhered with C3b are attached on red blood cells, and then presented to platelets and white blood cells, which induces plasma complement innate immunoreactions, red blood cells innate immunoreactions, platelets innate immunoreactions, white blood cells innate immunoreactions and lymphocyte adaptive immunoreaction. To study systemic hematogenic quick innate immunoreactions induced by pathogens （ yeasts, cancer cells etc. ） a simulation of natural experiment system in vitro was used. The result showed that there was a major pataway of red blood innate immunoreaction in systemic hematogenic immunoreaction, and that the complement and CR1 （ CD35 ） on red blood cells play vital roles in systemic hematogenic quick innate immunoreaction.