离子通道,抗心律失常药及其开发前景

Ion Channels,Antiarrhythmic Agents and the Perspective for Development of New Drugs

讨论了离子通道及其与心律失常的关系，介绍了近年来抗心律失常药开发研究的状况。提出：由于心律失常是由多种因素引起的，故抗心律失常药应对多种离子通道阻断，有效地防治严重心律失常，并克服单纯阻断ＩＫ·ｒ的Ⅲ类药的弊端。

Cardiac arrhythmia is a disease caused by the disturbance of ion channels.In this article,the ion channels in cardiac myocytes,antiarrhythmic agents and the perspective for development of new drugs were discussed.Results of CAST(Cardiac Arrhythmia Suppressing Trial) caused to develop the Class Ⅲ antiarrhythmic agents as the main direction. However, the mortality of the dsotalol group in SWORD(Survival with oral dsotalol trial) was double over the placebo group in 1994. Then, the purely selective IK·r blocking Class Ⅲ agents were in question.Since many factors are involved in cardiac arrhythmias,it is realized now that it is more promising for an antiarrhythmic agent to exert its action by blocking multiple ion channels,and thus,possibly to overcome shortcomings of simply blocking IK·r current Class Ⅲ agent.