银耳多糖等配基修饰对胰岛素降血糖活性的影响

Study on the hypoglycemic action of Ligand Modified Insulin in Rabbit

用聚乙二醇、聚蔗糖、葡聚糖及银耳多糖对胰岛素进行化学修饰。经兔血糖测定其降血糖活性显示，４种修饰复合物可将胰岛素在体内的作用时间从通常的３～４ｈ延长到８～１２ｈ．

Insulin was modified by PEG,Ficoll,Dextran or polysarcharides from spores of Tremella Fuciformis respectively.The activity of the four complexes to decrease the blood sugar in rabbit was investigated.The blood sugar assay showed that the hypoglycemic action of the four modified insulin complexes can last to 8～12 hours in vivo, compared to control of 3～4 hours.