不同浓度和pH利多卡因对蛙离体坐骨神经复合动作电位的影响

Effects of Lidocaine in Different Concentration and pH on Compound Action Potential of the Sciatic Nerve Isolated from Frog

目的：观察不同浓度和ｐＨ利多卡因对蛙离体坐骨神经复合动作电位的影响。方法：用５％碳酸氢钠调制出７种不同浓度和ｐＨ值的利多卡因溶液进行离体蛙坐骨神经标本实验，测定动作、电位衰减时间。结果和结论：将盐酸利多卡因溶液ｐＨ由４．５增加到６．０，可明显缩短其起效时间，增强神经阻滞作用，但对作用持续时间无明显影响。

Objective: The effects of lidocaine in different concentration and pH on compound action potential of the sciatic nerve isolated from frog were observed. Methods: The decline times of action potertial were recorded when the frog sciatic nerve preparation was merged in the 7 different lidocaine solutions treated with 5% bicarbonate. Results and Conclusion: Increasing the pH of lidocaine solutions from 45 to 60 could shorten the onset time and improve the quality of nerve blockade, but had no effect on the duration of action.