尖锐湿疣皮损中Smad7、Smurf1和Smurf2的表达及意义

Expression of Smad 7, Smurf 1 and Smurf 2 in condyloma acuminatum and its clinical significance

目的:探讨转化生长因子(TGF)-β信号转导途径中重要的负性调节因子Smad7、Smurf1和Smurf2在尖锐湿疣皮损中的表达及其意义。方法:采用EliVisionTMplus免疫组化技术分别检测尖锐湿疣和正常对照皮肤中Smad7、Smurf1和Smurf2的表达。结果:与对照正常皮肤相比,尖锐湿疣表皮中Smad7、Smurf1和Smurf2的表达水平显著上调。结论:尖锐湿疣皮损中Smad7、Smurf1和Smurf2的表达增强可能干扰TGF-β信号转导,有助于表皮角质形成细胞异常增殖,导致尖锐湿疣表皮过度增殖的组织病理学改变。

Objective： To investigate the expression and significance of Smad 7,Smurf 1 and Smurf 2 in condyloma acuminatum, which are negative regulators in TGF-β signaling. Methods： EliVisionTM plus immunohistochemical technique was used to detect the distribution and expression of Smad 7, Smurf 1 and Smurf 2 in condyloma acuminatum and normal control skin. Results： The expression of Smad 7, Smurf 1 and Smurf 2 in the epidermis of condyloma acuminatum was significantly up-regulated in comparison with that in normal control skin. Conclusions： The expression of Smad 7, Smurf 1 and Smurf 2 is up-regulated in the epidermis of condyloma acuminatum, which might contribute to the formation and progression of aberrant epidermal hyperplasia in condyloma acuminatum via blocking TGF-β signaling pathway.