银屑病患者外周血白细胞膜CD14和血浆可溶性CD14表达水平的意义

mCD14 expression of the peripheral blood leukocytes and sCD14 expression of the plasma in patients with psoriasis vulgaris

目的:了解银屑病患者外周血白细胞膜CD14(mCD14)和血浆中可溶性CD14(sCD14)的表达水平,探讨内毒素信号通路激活与银屑病的关系。方法:采用流式细胞仪和ELISA法分别检测银屑病患者外周血白细胞mCD14的表达水平和血浆sCD14的含量。结果:患者组外周血白细胞mCD14表达水平与血浆中sCD14含量均较正常对照组升高,差异有统计学意义。结论:G-细菌感染所产生的内毒素使外周血白细胞mCD14和sCD14水平升高,可能导致银屑病发病或病情加重。

Objective： To investigate the expression of mCD14 on peripheral blood leukocytes and the plasma level of sCD14 in patients with psoriasis vulgaris, and explore the relationship between the activation of endotoxin signal transduction pathway and the pathogenesis of psoriasis. Methods： The expression of mCD14 on peripheral blood leukocytes and the plasma level of sCD14 in patients with psoriasis vulgaris were determined by flow cytometry and ELISA, respectively. Results： The mCD14 expression of peripheral blood leukocytes and the plasma level of sCD14 in patients were significantly increased compared with those in the healthy controls （P〈 0.05）. Conclusion： The endotoxin produced by Gram negative bacteria causes the increase of the levels of mCD14 and sCD14 in patients with psoriasis, which is probably related to the pathogenesis of psoriasis.