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Ang-1,Ang-2及其受体Tie2在增生期血管瘤中的表达 被引量：3

Expression of Angiopoietin-1,Angiopoietin-2 and Tie2 in Proliferative Hemangioma
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摘要 目的:检测血管生成素-1,-2(Ang-1,-2)及其受体Tie2在皮肤增生期血管瘤中的表达并探讨其意义。方法:应用半定量RT-PCR技术检测26例皮肤增生期血管瘤及20例正常组织中Ang-2、Ang-1及Tie2 mRNA的表达,并结合计算机图像分析比较上述RNA在两组中的表达。结果:Ang-2 mRNA在增生期血管瘤中的表达显著高于正常组织(P<0.05);Ang-1 mRNA在增生期血管瘤中的表达显著低于正常组织(P<0.05),而Tie2 mRNA的表达在血管瘤与正常组织间的表达无明显差异(P>0.05)。结论:Ang-1、Ang-2可能与血管瘤的发生、发展有关。 Objective： To examine the expression of Ang 1, -2 and Tie2 in proliferative hemangioma and to explore their functions in the development of hemangioma. Methods： The expression of Ang-1, Ang-2 and Tie2 were detected in 26 specimens of proliferative hemangioma and 20 normal tissues by semiquantitative RT-PCR, the level of Ang-1, Ang-2 and Tie2 were analyzed by computer dig ital image analysis system. Results： The Ang 2 expression was significantly higher and Ang-1 ex- pression was lower in proliferative hemangiomas than in normal tissues （both P〈0.05）, but the Tie2 expression results showed no difference between the two groups. Conclusion： There is a close relationship between Ang-1, Ang-2 and the proliferation of hemangiomas.
作者 汤洁 刘世清 李皓桓 刘文俊 郑慧锋
机构地区 武汉大学人民医院骨科
出处 《武汉大学学报（医学版）》 CAS 2008年第5期623-625,共3页 Medical Journal of Wuhan University
基金 武汉市青年科技晨光计划资助项目(编号:200750731256)
关键词 血管生成素 增生期血管瘤 RT-PCR Angiopoietin Proliferative Hemangioma RT-PCR
分类号 R654.3 [医药卫生—外科学]
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参考文献10

  • 1Soto J. Pathology and pathogenesis of haemangiomas [J].An Sist Sani.t Navar, 2004,27:27-31.
  • 2Nilesh MP, Naranjan SD, Dev DS, et al. Angiogenesis-a new target for future therapy[J].Vascular Pharmacology, 2006,44:265-274.
  • 3Fiedler U, Augustin HG. Angiopoietins: a link be- tween angiogenesis and inflammation[J]. Trends in Immunology,2006, 27(12) : 552-558.
  • 4陈林莺,张声,林建银,黄培生.促血管生成素-2对胃癌血管生成的双向效应[J].中华肿瘤杂志,2004,26(3):161-164. 被引量：21
  • 5Yin-Shan Ng,Dominik Krilleke,David T. Shima. VEGF function in vascular pathogenesis[J]. Experimental Cell Research, 2006, 312 : 527-537.
  • 6Nagy JA, Senger DR. VEGF-A, cytoskeletal dynamics, and the pathological vascular phenotype[J]. Experimental Cell Research, 2006, 312 : 538-548.
  • 7Arai F, Hirao A,Ohmura M, et al. Tie2/Angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche[J]. Cell,2004,118:149-161.
  • 8Tanaka F, Ishikawa S,Yanagihara K, et al. Expression of angiopoietins and its clinical significance in non- small cell lung cancer[J]. Cancer Res,2002,62 (23):7 124-7 129.
  • 9李超,冯红超,宋宇峰.口腔鳞癌中Angiopoietin-2的表达与肿瘤血管生成及成熟的关系研究[J].中国肿瘤临床,2005,32(13):729-734. 被引量：7
  • 10Perry maco gains derm BN, Govindarajan B, Bhandarkar SS, et al. Pharlogic blockade of angiopoietin-2 is efficacious a- t model hemangiomas in mice[J]. Investigative atology,2006,126(10) :2 316-2 322

二级参考文献32

  • 1Folkman J. The role of angiogenesis in tuner growth. Semin Cancer Biol, 1992, 3: 65-71.
  • 2Peoch M, Farion R, Hiou A, et al. Immunohistochemical study of VEGF, angiopoietin 2 and their receptors in the neovascularization following microinjection of C6 glioma cells into rat brain. Anticancer Res, 2002, 22: 2147-2151.
  • 3Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie-2, that disrupts in vivo angiogenesis. Science, 1997,277 : 55-60.
  • 4Koga K, Todaka T, Morioka M, et al. Expression a angiopoietin-2 in human glioma cells and its role for angiogenesis. Cancer Res, 2001, 61 :6248-6254.
  • 5Ahmad SA, Liu W, Jung YD, et al. The effects of angiopoietin-1 and-2 on tumor growth and angiogenesis in huraan colon cancer. Canoex Res,2001, 61: 1255-1259.
  • 6Holash J, Maisonpierre PC, Compton D, et al. Vessel cooption,regression, and growth in tumors mediated by angiopoietins and VEGF.Science, 1999,284: 1994-1998.
  • 7Yu Q, Stamenkovic I. Angiopoietin-2 is implicated in the regulation of tumor of angiogenesis. Am J Pathol, 2001, 158: 563-570.
  • 8Veikkola T, Alitalo K. Dual Role of Ang2 in postnatal angiogenesis and lymphangiogenesis. Dev Cell, 2002, 3: 302-304.
  • 9Etoh T, houe H, Tanaka S, et al. Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases. Cancer Res, 2001, 61: 2145-2153.
  • 10Maeda K, Chung YS, Takatsuko S, et al. Tumor angiogenesis as a predictor of recurrence in gastric carcinoma. J Clin Oncol, 1995, 13:477-481.

共引文献24

同被引文献41

  • 1Lund EL, Hag A, Olsen MWB, et al. Differential regulation of VEGF, HIF1, and angiopoietin-1, -2, and-4 by hypoxia and ionizing radiation in human glioblastoma. Int J Cancer, 2004, 108 (6) :833-838.
  • 2Daly C, Pasnikowski E, Burova E, et al. Angiopoietin-2 func- tions as an autocrine protective factor in stressed endothelial cells. Proc Natl Acad Sci USA, 2006, 103(42) :15 491-15 496.
  • 3Gill KA, Brindle NP. Angiopoietin-2 stimulates migration of en- dothelial progenitors and their interaction with endothelium. Bio- chem Biophys Res Commun, 2005, 336(2) ..392-396.
  • 4Malsonpierre PC, Suri C, Jones PE, et al. Angiopoietin-2, a nat- ural agonist for Tie2 that disrupts in vivo angiogenesis. Science, 1997, 277(5 322): 55-60.
  • 5Jianhua Huang ,Makoto Inoue ,Mamoru Hasegawa , et al. Sendai viral vector mediated angiopoietin-1 gene transfer for experimental ischemic limbdisease. Angiogenesis, 2009, 26(12) :243 246.
  • 6Scharpfenecker M, Fiedler U, Reiss Y, et al. The Tie2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism. J Cell Sci, 2005, 118(4) :771- 780.
  • 7Lee SW, Kim WJ, Jun HO, et al. Angiopoietin-1 reduces vascular endothelial growth factor-induced brain endothelial permeability via upregulation of ZO-2. Int J Mol Med, 2009, 23(2):279- 284.
  • 8Suri C, Jones PF, Patan S, et al. Requisite role of angiopoietin- 1, aligand for the Tie2 receptor, during embryonic angiogenesis. Cell, 1996, 87(7):1 171-1 180.
  • 9Reiss Y, Knedla A, Tal AO, et al. Switching of vascular phenotypes within a murine breast cancer model induced by angio- poietin-2. J Pathol, 2009, 217(4): 571-580.
  • 10Szarvas T, Jger T, Droste F, et al. Serum levels of angiogenic factors and their prognostic relevance in bladder cancer. Pathol Oncol Res, 2008, 20(12):982-987.

引证文献3

二级引证文献27

武汉大学学报（医学版）
2008年 第5期

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