摘要
A breakthrough has recently been made in the studies on pathogenesis of HIV disease,which result in some new theories.New strategies for HIV drug and vaccine development are emerging in the impact of these new understandings.The intestinal infection hypothesis proposes that HIV disease can be regarded as some kind of infectious disease of gut immune system as the major HIV infection is located in intestine.The acute catastrophe hypothesis suggests that the subsequent pathological changes are the fallout from a mucosal catastrophe of acute intestinal HIV infection,in which the majority of CD4+ T cells are deleted due to infection.The general immune overactivation hypothesis proposes that the general immune overactivation is harmful to patient as it increases the cell susceptibility to HIV infection and supportiveness of HIV replication.The host proteins related to HIV replication can be new targets for HIV drug discovery.The mucosal vaccine strategies,which attempt to induce HIV specific neutralizing antibodies on mucosal surface may be the first choice in development of prophylactic HIV vaccines.Induction of tolerance may be one of the strategies for HIV therapeutic vaccines because HIV disease can be regarded as autoimmune disease caused by HIV infection.
A breakthrough has recently been made in the studies on pathogenesis of HIV disease, which result in some new theories. New strategies for HIV drug and vaccine development are emerging in the impact of these new understandings. The intestinal infection hypothesis proposes that HIV disease can be regarded as some kind of infectious disease of gut immune system as the major HIV infection is located in intestine. The acute catastrophe hypothesis suggests that the subsequent pathological changes are the fallout from a mucosal catastrophe of acute intestinal HIV infection, in which the majority of CD4^+ T cells are deleted due to infection. The general immune overactivation hypothesis proposes that the general immune overactivation is harmful to patient as it increases the cell susceptibility to HIV infection and supportiveness of HIV replication. The host proteins related to HIV replication can be new targets for HIV drug discovery. The mucosal vaccine strategies, which attempt to induce HIV specific neutralizing antibodies on mucosal surface may be the first choice in development of prophylactic HIV vaccines. Induction of tolerance may be one of the strategies for HIV therapeutic vaccines because HIV disease can be regarded as autoimmune disease caused by HIV infection.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2008年第9期1861-1864,共4页
Chinese Journal of Pathophysiology
基金
"973"国家重点基础研究资助项目(No.2004CB720100No.2006CB504201)
广州市科技计划资助项目(No.2006Z1-E0091)
关键词
HIV
肠黏膜
免疫过度活化
艾滋病
HIV
Intestinal mucosa
Immune overactivation
AIDS vaccines