摘要
目的:在温和酸性条件下,对人参皂苷20(P1)原人参二醇组中的两种主要单体皂苷Rd和Rb1酸水解情况进行研究。方法:水解产物采用高效液相色谱法(HPLC)标识。结果:人参皂苷Rd降解产生次级苷20(P1)Rg3和F2;Rb1水解后,除以上两种次级苷20(P1)Rg3和F2,主产物表明为Rd。结论:HPLC对人参皂苷在温和酸性条件下降解产物的检测结果是令人满意的,有助于了解皂苷的相互转化特性及其代谢机制。
OBJECTIVE: To study the hydrolysis of ginsenoside Rd and Rb1, two kinds of main ginsenosides of the 20 (P1)protopanaxadiol group, under mild acidic conditions. METHOD: The hydrolysates were examined by high performance liquid chromatography (HPLC). RESULTS: Ginsenoside Rd was decomposed to yield the prosapogenins: 20 (P1)Rg3 and F2; the Rb1prosapogenins were Rd, 20 (P1)Rg3 and F2. CONCLUSION: The results of degradation reaction of ginsenoside under mild acidic conditions monitored by HPLC are acceptable. They will help as to learn changing characteristics and catabolic mechanism of ginsenosides.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1997年第12期772-774,共3页
Chinese Pharmaceutical Journal