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洛伐他汀影响人高转移卵巢癌细胞系HO-8910PM转移相关能力的研究 被引量：2

Effect of lovastatin on metastasis-associated ability of highly metastatic ovarian carcinoma cell line HO-8910PM
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摘要 目的研究洛伐他汀对人高转移卵巢癌细胞系HO-8910PM转移相关能力的影响。方法分别运用MTT法、Transwell小室法、细胞粘附人工重组基底膜实验检测洛伐他汀对HO-8910PM细胞的细胞毒作用,对细胞的侵袭能力和趋化运动及对细胞粘附能力的影响。结果洛伐他汀作用HO-8910PM细胞6h后能抑制其体外侵袭、趋化运动和粘附能力,其中8μmol/L抑制率分别为(79.18±0.21)%、(59.40±0.80)%和(14.08±1.28)%。结论洛伐他汀能有效地抑制人高转移卵巢癌细胞系HO-8910PM的侵袭、趋化运动和粘附能力,是潜在的抗肿瘤转移药物。 Objective To investigate the effect of lovastatin on the metastasis-associated ability of highly metastatic ovarian carcinoma cell line HO-8910PM. Methods After pretreatment with lovastatin, cytotoxicity, invasion and migration capacity, and adhesion potential of HO-8910PM cells were determined by MTT assay, Transwell chamber assay and cell matrigel adhesion assay, respectively. Results Lovastatin pretreatment inhibited the invasion, migration and adhesion capacity of HO-8910PM cells after 6 hours, and its inhibitory rates at dose of 8 μmol/L, were （79.18 ± 0.21） %, （59.40 ± 0.80） % and （ 14.08 ± 1.28） %, respectively. Conclusion Lovastatin may be a potential antitumor drug by inhibiting the invasion, migration and adhesion capacity of HO-8910PM cells.
作者 张建和 符伟玉 覃燕梅 莫丽儿 梁念慈
机构地区 广东医学院化学教研室 广东医学院生物化学与分子生物学教研室
出处 《广东医学院学报》 2008年第4期373-376,共4页 Journal of Guangdong Medical College
基金 湛江市科技攻关项目(No.2007C04002)
关键词 洛伐他汀 侵袭 运动 转移 卵巢癌 lovastatin invasion migration metastasis ovarian carcinoma
分类号 R730 [医药卫生—肿瘤]
  • 相关文献

参考文献9

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共引文献2

同被引文献9

  • 1Feng C, Han A, Ye C, et al. The HMG-CoA reductase pathway, statins and anglo- prevention [ J ]. Semin Ophthalmol, 2006, 21(1) :29-35.
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  • 5Farina H G, Bublik D R, Alonso D F, et al. Lovastatin alters cytoskeleton organization and inhibits experimental metastasis of mammary carcinoma cells[J]. Clin Exp Metastasis, 2002, 19(6) : 551-559.
  • 6Wang I K, Lin-Shiau S Y, Lin J K. Suppression of invasion and MMP-9 expression in NIH 3T3 and v-H-Ras 3T3 fibroblasts by Simvastatin through inhibition of ras isoprenylation [J]. Oncology, 2000, 59(3):245-254.
  • 7van de Donk N W, Lokhorst H M, Nijhuis E H, et al. Geranylgeranylated proteins are involved in the regulation of myeloma cell growth[J]. Clin Cancer Res, 2005,11(2 Pt 1) : 429-439.
  • 8张建和,符伟玉,覃燕梅,梁念慈.洛伐他汀对高转移卵巢癌细胞HO-8910PM细胞周期和增殖的影响[J].实用癌症杂志,2008,23(3):227-229. 被引量：2
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广东医学院学报
2008年 第4期

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