芝麻对大剂量维生素D_3致大鼠动脉钙化的治疗作用

Effect of sesame on angiosteosis induced by high-dose of vitamine D_3 in rats

目的研究芝麻对大鼠血管钙化的治疗作用。方法40只SD雌性大鼠随机分成正常组、VitD3模型组、辛伐他汀组和芝麻组4组,每组均为10只。用大剂量VitD3灌胃的方式造成大鼠血管钙化模型,同时分别用辛伐他汀和芝麻进行治疗,比较VitD3模型组和各治疗组大鼠主动脉血管钙化程度及其血脂水平。结果芝麻组的主动脉弓血管钙化面积为(1.29±0.20)%,腹主动脉血管血钙含量(14.7±6.7)μmol/g,明显低于VitD3模型组(60.7±16.7)%和(22.8±8.8)μmol/g(均P<0.01)。VitD3模型组大鼠的血清总胆固醇(TC)含量和低密度脂蛋白胆固醇(LDL-C)含量明显升高,血清甘油三酯(TG)及高密度脂蛋白胆固醇(HDL-C)含量明显降低(P<0.05);与模型组比较,辛伐他汀组的TC含量无明显差异,芝麻组的TC含量则明显下降(P<0.05);辛伐他汀组的HDL-C明显升高(P<0.05),芝麻组的HDL-C含量则无明显变化。结论芝麻对VitD3造成的大鼠血管钙化具有预防治疗作用。

Objective To study the therapeutical effect of sesame on rats with angiosteosis. Methods Forty SD rats were randomly divided into normal group, model group, simvastatin group and sesame group. Angiosteosis model was established by intragastrical administration of high-dose of vitarnine 133. Simvastatin group and sesame group were treated by simvastatin and sesame, respectively. Angiosteosis,blood fat and calcium were detected in all groups. Results Sesame treatment resulted in the improvement of angiosteosis area and blood calcium level in blood vessels as compared with model goup （ P 〈 0.01）. Total cholesterol （TC） and LDL-C levels were significantly higher, but triglyeeride （TG） and HDL-C levels were lower in model group than those in normal group （P〈 0.05）. Compared with model group, simvastatin or sesame treatment only induced the increase of HDL-C content or decrease of TC concentration （ P 〈 0.05 ）. Conclusion Sesame treatment possesses therapeutic effect on angiosteosis induced by vitarnine 133 in rats.