脑脊液中cAMP含量在电针降温与电针降温耐受性中的作用

The Role of cAMP Contents in the Cerebrospinal Fluid in Electroacupuncture Hypothermia and Its Tolerance

本实验观察了电针降温作用与电针降温产生耐受时，脑脊液（CSF）环-磷酸腺苷（cAMP）含量的变化。结果如下：（1）给家兔静脉注射内生致热原（EP）后，动物出现明显的发热效应，同时CSF中cAMP含量明显升高。（2）电针可使发热动物肛温明显降低，同时CSF中cAMP含量也较发热组显著降低。（3）电针降温耐受组电针后体温无明显改变，同时CSF中cAMP含量与发热组比较，无明显差异。上述实验结果说明，电针后CSF中cAMP含量降低在针刺降温中起重要作用；而连续电针刺激也可引起针刺降温耐受性，其中CSF中cAMP含量则无明显变化。

The changes of cAMP contents in the cerebrospinal fluid (CSF) under electroacupuncture hy-pothermia and electroacupuncture hypothermia tolerance were studied in rabbits. The results were fol-lows: (1) The body temperature rose markedly after injection of the endogenous pyrogen (EP), and cAMP contents in CSF were increased rnarkedly at the same time. (2) ElectroacuPuncture could obvi-ously decreased the body temperature induced by EP and cAMP contents were also decreased apparent-ly. (3) Compared with the results of EP induced fever group, in eIectroacupuncture tolerance group there was no significant change in fehrile response and cAMP contents in CSF after elec-troacupuncture. The experimental results indicated that the continuous electroacupuncture could lead to the acupunclure hypothermia tolerance, and its mechanism might be related to cAMP contents in CSF.