细胞增殖抑制基因、p21WAF1蛋白在非小细胞肺癌组织中的表达及其意义

Expression and significance of HSG/Mfn2 and P21 WAF1 in non-small cell Lung cancer

目的探讨细胞增殖抑制基因（HSG／Mfn2）、p21WAF1蛋白在非小细胞肺癌中的表达及相关性。方法采用免疫组化sP法检测92例非小细胞肺癌中HSG／Mfn2、p21WAF1蛋白的表达。结果HSG／Mfn2在肺鳞癌、腺癌、非癌肺组织中吸光度值分别为15．06±2．73、12．21±2．96、10．36±3．60，差异有统计学意义（P〈0．05），并与肺癌分化程度有关。p21WAF1蛋白在肺鳞癌、腺癌、非癌肺组织中吸光度值分别为3．16±0．98、3、44±0．22、0．06±0．32，肺鳞癌和腺癌组织与非癌组织比较差异均有统计学意义（均P〈0．05），与分化程度、淋巴结转移有关。结论HSG／Mfn2，p21WAF1蛋白与肺癌发生、发展密切相关。二者在肺癌组织中的表达呈正相关：

Objective To investigate the expression of hyperplasia suppressor gene （ HSG）/mitofusin 2 （Mfn2） and P21 WAF1 in non-small cell lung cancer（NSCLC） . Methods The expression of（ HSG/Mfn2 ） and P21 WAF1 was detected in 92 cases of NSCLC samples by immunohistochemistry（ SP）, Results The absorptance value of the expression of HSG/Mfn2 in squamous cell carcinoma, adenocarcinoma, and non-cancer tissue were 15.06 ± 2.73,12.21 ± 2.96 and 10.36 ± 3.60,respectively （ P 〈 0.05 ） , and they were associated with tumor differentiation. The absorptance value of the expression of P21WAF1 in squamous cell carcinoma,adenocarcinoma,and non-cancer tissue were 3.16 ±0.98,3.44 ±0.22,0, 06 ±0.32. The expression of P21 WAF1 in squamous cell carcinoma and adenocarcinoma was higher than that in non-cancer tissue （ P 〈 0.05 ） , and was closely associated with tumor differentiation and lymph node metastasis. Conclusion HSG/Mfn2,P21WAF1 is closely related to the pathogenesis and development of lung cancer . There is positive correlation between the HSG/Mfn2 and P21WAFI in lung cancer.