摘要
目的探讨绿原酸对糖尿病大鼠肾脏氧化及抗氧化系统的影响。方法将36只大鼠随机分成N组（正常组）、DM组（糖尿病组）及CA组（绿原酸干预组）。DM组和CA组造糖尿病模型，分别给予腹腔注射生理盐水和绿原酸，饲养10周后，测定血糖、肾脏重量、体重变化，肾皮质超氧化物歧化酶（SOD）、谷胱甘肽过氧化酶（GSH—PX）、丙二醛（MDA）含量及尿微量白蛋白排泄率（UAER）。结果与DM组大鼠相比，CA组大鼠血糖无明显差别，而肾重、体重明显增加，肾皮质SOD、GSH—PX活性明显上升，MDA含量及UAER则明显减少（均P〈0．05）。结论绿原酸有改善糖尿病大鼠的一般状况，提高抗氧化能力，抑制氧化应激，减少尿蛋白的作用。
Objective To investigate the effect of Chlorogenic acid on oxidative and antioxidative system of kidney in diabetic rats. Methods 36 rats were randomly divided into three groups：normal group（ N group ） , diabetes mellitus group （ DM group） and diabetes group treated with chlorogenic acid （ CA group）. Ten weeks later,blood glucose, weight of body and kidney, the activity of superoxide dismutase （ SOD ） and glutathione peroxidase （ GSH-PX ） lipidperoxidation（MDA） ,urinary albumin excretory rate（UARE） in renal tissue were measured. Results The levels of blood glucose were not significantly different between DM group and CA group , but the weight of rats and kidney and the activity of SOD and GSH-PX in CA group were higher than DM group, and MDA and UAER of CA group were lower（ P 〈 0.05 for each）. Conclusion Chlorogenic acid is effective in improving the antioxidativity, inhibiting oxidative stress and decreasing urinary albumin.
出处
《中国综合临床》
北大核心
2008年第10期963-965,共3页
Clinical Medicine of China
基金
河南省医学科技攻关计划资助项目（200703039）
关键词
糖尿病肾病
绿原酸
氧化应激
大鼠
Diabetic nephropathy
Chlorogenic acid
Oxidative stress
Rat
