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绿原酸对糖尿病大鼠肾脏氧化应激作用的实验研究 被引量:3

Experimental study on effect of chlorogenic acid on oxidative stress of kidney in diabetic rats
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摘要 目的探讨绿原酸对糖尿病大鼠肾脏氧化及抗氧化系统的影响。方法将36只大鼠随机分成N组(正常组)、DM组(糖尿病组)及CA组(绿原酸干预组)。DM组和CA组造糖尿病模型,分别给予腹腔注射生理盐水和绿原酸,饲养10周后,测定血糖、肾脏重量、体重变化,肾皮质超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH—PX)、丙二醛(MDA)含量及尿微量白蛋白排泄率(UAER)。结果与DM组大鼠相比,CA组大鼠血糖无明显差别,而肾重、体重明显增加,肾皮质SOD、GSH—PX活性明显上升,MDA含量及UAER则明显减少(均P〈0.05)。结论绿原酸有改善糖尿病大鼠的一般状况,提高抗氧化能力,抑制氧化应激,减少尿蛋白的作用。 Objective To investigate the effect of Chlorogenic acid on oxidative and antioxidative system of kidney in diabetic rats. Methods 36 rats were randomly divided into three groups:normal group( N group ) , diabetes mellitus group ( DM group) and diabetes group treated with chlorogenic acid ( CA group). Ten weeks later,blood glucose, weight of body and kidney, the activity of superoxide dismutase ( SOD ) and glutathione peroxidase ( GSH-PX ) lipidperoxidation(MDA) ,urinary albumin excretory rate(UARE) in renal tissue were measured. Results The levels of blood glucose were not significantly different between DM group and CA group , but the weight of rats and kidney and the activity of SOD and GSH-PX in CA group were higher than DM group, and MDA and UAER of CA group were lower( P 〈 0.05 for each). Conclusion Chlorogenic acid is effective in improving the antioxidativity, inhibiting oxidative stress and decreasing urinary albumin.
出处 《中国综合临床》 北大核心 2008年第10期963-965,共3页 Clinical Medicine of China
基金 河南省医学科技攻关计划资助项目(200703039)
关键词 糖尿病肾病 绿原酸 氧化应激 大鼠 Diabetic nephropathy Chlorogenic acid Oxidative stress Rat
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