儿童复发性特发性血小板减少性紫癜病毒感染与白细胞介素-2水平的临床意义

Clinical significance of virus infection and serum interleukin-2 levels in recurrent childhood idiopa thicthrombocytopenic purpura.

目的探讨复发性特发性血小板减少性紫癜（ITP）病毒感染与白细胞介素-2（IL-2）水平的临床意义。方法对健康儿童（正常对照组）及复发性ITP患儿（ITP组）各40例采用酶联免疫吸附法（ELISA）检测血巨细胞病毒（CMV）、EB病毒（EBV）、腺病毒（ADV）、单疱病毒（HSV）特异性IgM抗体，采用放射免疫法检测血II。．2。结果ITP组中CMV－IgM、EBV－IgM、ADV－IgM、HSV－IgM阳性例数分别为18、14、5、3例，正常对照组分别为3、2、1、0例，两组比较差异均有统计学意义（P〈0，01或P〈0．05）；ITP组血IL－2水平为（0．35±0．12）μg/L，显著低于正常对照组的（0．61±0．17）μg／L，两组比较差异有统计学意义（P〈0．05）。结论检测儿童复发性ITP DNA病毒抗体IgM及血IL-2水平能反映该病感染及免疫状况，对深入了解其发病机制并指导临床治疗有重要意义。

Objective To study the clinical significance of virus infection and serum intedeukin-2 （ IL-2 ） levels in recurrent childhood idiopathic thrombocytopenic purpura （ ITP ）. Methods The cytomegalovirus （ CMV ） , epstein-Barrvirus （ EBV ） ,adenovirus （ ADV） , herpesvirus （ HSV ） antibodies IgM and IL-2 levels were determined in the serum of 40 childhood with recurrent childhood ITP as well as in 40 normal controls with ELISA and RIA. Results The CMV-IgM positive cases were 18,EBV-IgM were 14,ADV-IgM were 5,HSV-IgM were 3. In the controls, those were 3,2,1, and 0 respectively （ P 〈 0.05 or P 〈 0.01 ）. The serum IL-2 （0.35 ± 0.12） μg/L levels were significantly lower than those in the controls [ （ 0.61 ± 0. 17 （ μg/L, P 〈 0.05 ]. Conclusion DNA virus antibodies and IL-2 levels can reflect virus infection and immune condition of diseases in recurrent childhood ITP. It is important to comprehend the mechanism of recurrent childhood ITP for guiding clinical treatment.