摘要
目的观察血清铁、铁蛋白及转铁蛋白与冠状动脉狭窄的关系，探寻冠心病的发病原因。方法对315例冠心病患者行冠状动脉造影和血清铁、铁蛋白及转铁蛋白的测定，采用Gensini评分系统衡量冠状动脉造影结果。按照Gemini评分的三分位间距将观察对象分为3组，应用方差分析研究铁代谢指标在3组中的分布情况，应用多因素回归分析研究Gensini评分与铁代谢指标的关系。结果单因素方差分析显示，血清铁、血清铁蛋白及血清转铁蛋白／血清铁蛋白比值与Gensini评分有相关性（相关系数分别为6．162、7．191和4．380，均P〈0．05）；多因素逐步线性回归分析显示，血清铁蛋白与冠状动脉狭窄程度的评分独立相关（其偏相关系数为0．240，P〈0．01）。结论血清铁蛋白与冠状动脉狭窄独立相关。
Objective To investigate the relationship between serum iron, ferritin （SF） , transferrin （TRF） and coronary artery stenosis as well as to find the possible cause of coronary heart disease. Methods All the 315 patients underwent coronary angiography. Serum iron, SF and TRF were measured. All patients were divided into three groups according to the Gensini score. The distribution of serum iron, SF,TRF in the three groups underwent analysis of variance and the relationship between serum iron,SF,TRF and the Gensini score were further investigated by means of muhiple linear regression analysis. Results The analysis of one-way variance showed that serum iron, SF and TRF/SF were associated with the Gensini score （ coefficient correlation = 6. 162, 7. 191 and 4. 380, P 〈0.05）. Muhiple linear regression analysis adjusted for many risk factors for coronary heart disease showed that SF had independent association with the Gensini score. （ r = 0. 240, P 〈 0.01 ）. Conclusion Ferritin is independ- ently associated with coronary artery stenosis.
出处
《中国综合临床》
北大核心
2008年第10期1045-1047,共3页
Clinical Medicine of China
