肺通气功能与呼吸阻抗的临床研究

Clinical study on lung vaentilative function and respiratory impedance

目的探讨常规肺通气功能测定指标与脉冲振荡法测定的呼吸阻抗对几种常见呼吸系统疾病的临床诊断价值。方法测定并分析正常人(对照组)、慢性阻塞性肺疾病(COPD)、肺癌、胸腔积液患者的肺通气功能与呼吸阻抗的主要指标及其相关关系。结果对照组、肺癌组FVC显著高于慢阻肺组与胸腔积液组(P<0.01,P<0.05),呼吸阻抗显著低于慢阻肺组(P<0.01,P<0.05);对照组通气功能指标与Zrs、Fres、R20、X5成负相关关系,与R5成正相关关系。结论呼吸阻抗能较好地反映气道阻力及肺顺应性,判断阻塞部位,测定方法简单,能更客观、全面的反映呼吸功能的改变,具有较高的临床应用价值。

Objective To explore the diagnostic value of conventional indicators of lung ventilative function and respiratory impedance detected by impulse oscillometry system（IOS） on several common respiratory diseases. Methods The main indicators of lung ventilative function and respiratory impedance were detected and their correlations were analyzed in chronic obstructive pulmonary disease（COPD）,lung cancer, pleural effusion and normal controls. Results FVC in control, lung cancer groups was significantly higher than that in COPD and pleural effusiofl groups（P〈0.01,or P〈0.05）. The respiratory impedance was lower than that in COPD group（P〈0.01 ,or P〈0.05）. The indicators of lung ventilative function were negatively related to Zrs,Fres,R20 and X5 and positively related to R5. Conclusion Respiratory impedance can better reflect the airway resistance and lung compliance,and judge the block sites. It has g higher practical value in clinic with simple determination method and more objective and comprehensive reflection of the airway resistance and lung compliance.