阿托伐他汀改善冠心病心力衰竭患者心功能的作用

Effect of atorvastatin on improvement of cardiac function in patients with coronary heart disease and heart failure

目的观察国产阿托伐他汀对冠心痛心力衰竭患者心功能和高敏C反应蛋白（hs-CRP）的影响。方法确诊为冠心痛心力衰竭患者50例（心功能Ⅲ～Ⅳ），随机分为治疗组（25例）和对照组（25例），两组均给予基础治疗，治疗组加服阿托伐他汀10mg／d，治疗前及治疗后12周时测定血清hs-CRP水平，采用超声心动图测量左室射血分数（LVEF）。结果两组患者12周时心功能指标及血清hs-CRP水平均较治疗前明显改善，治疗组LVEF升高，与对照组比较差异有统计学意义（P〈0．01）。结论冠心痛心衰患者在基础治疗中，加用阿托伐他汀可以进一步改善心功能，抑制心肌微炎症可能为其中机制之一。

Objective To observe the effect of atorvastatin on cardiac function and hypersensitive C-reaction protein（hs-CRP） in the patients with coronary heart disease（CHD） and heart feilure（HF）. Methods Fifty patients with CHD and HF（NYHA Ⅲ-Ⅳ） were randomly divided into treatment group（25 cases） and control group（25 cases）. All patients were given basic treatment. The treatment group was added atorvastatin 10mg/d for 12 weeks. The serum level of hs-CRP was measured before and after treatment. The left ventricular ejection fraction （LVEF） was examined by echocardiography. Results The data of cardiac function and hs-CRP in both groups obviously improved after treatment. The LVEF of the treatment group improved significantly and the level of hs- CRP decreased （P〈0.01）. Conclusion On the basic treatment in the patients with HF and CHD,the heart function is further improved by atorvastatin,one of probably underlying mechanisms is that atorvastatin inhibits the myocardial micro-inflammation.