珠海地区311例药品不良事件报告分析

Adverse Drug Events:Analysis of 311 Cases in Zhuhai Area

目的：了解珠海地区药品不良事件（ADE）发生的特点及规律。方法：对广东省不良反应监测中心珠海工作站于2005年8月～2006年12月收集到的311例ADE报告，从患者性别、年龄、给药途径、涉及药物品种、涉及器官或系统及临床表现等进行统计分析。结果：抗感染药的ADE发生率最高，有213例（占68．49％）；ADE主要临床表现为皮肤及其附件损害，有160例（占51.45％），经过相应的治疗均恢复正常。结论：医务工作者在用药前应询问患者自身及家族过敏史，注意药物配伍禁忌，用药后认真观察，尽量减少ADE发生。

OBJECTIVE： To explore the characteristics and general pattern of adverse drug events （ADE） in Zhuhai area. METHODS： 311 ADE cases collected from Aug. 2005 to Dec. 2006 by Zhuhai workstation of Guangdong ARD Monitoring Center were statistically analyzed in respect of patients＇ age and sex, route of administration, category of drugs involved, ADR- involving organs/systems and clinical manifestations etc. RESULTS： The antiinfective drugs showed highest incidence rate of AIDE, which caused AIDE in 213 cases （68.49%） . The most common clinical manifestations of the AIDE were the damage of skin and adnexa, accounting for 51.45% （160 cases）, all recovered after receiving corrsponding treatment. CONCLUSION： Allergic history of patients and their family members should be inquired in detail before the use of drugs and high alert should be given to pharmaceutical incompatibility, and the patients should be given fully attention after medication to reduce the incidence of ADE.