2Shankland S J. Cel cycle regulatory proteins in glomendar disease[J]. Kid ney Int, 1999,56(10) :1208.
3Schena F P, Cesualdo L. Pathogenesic mechanisms of diabetic nephorpathy[J] ,J Am Soe Nephml, 2005,16(Sappll) : S30.
4ZhiH, ZhaoH, YingJ, et al. Phenotypic alteration of mesangial cells in patients with diabetic nephropathy from renal biopsy specimen. J Am Soc Nephrol, 1999,10 : 13.
8Hill-Kapturczak N, TruongL, Thamilselvan V, et al. Smad7-dependent regulation of heme exgyenase-1 by transforming growth- factor-β in human renal epithelial cells[J]. J Biol chem. 2000,275 (52) :40904-40909.
9ChengF, Grande JP. Transforming growth factor-β signal transduetion and progressive renal disease [J]. Experimental Biolog And Medicine,2002,227: 946-956.
10Ziyadeh FN. Significance of tubulointerstital changes in diabetes renal disease. Kidney Int, 1996,54(Suppl) :S10.
3[2]Meyer IJ,Szukics B,Neubauer K,et al.Extracellular matrix proteins as early markers in diabetic nephropathy.Eur J Clin Cem Clin Biochem,1995,33 (1):211.
4[3]Phillips AO,Steadman R,Diabetic nephropathy:the central role of renal proximal tubular cells in tubulointerstitial injury.Histol Histopathol,2002,17 (1):247-252.
5[4]Nangatu M,Mechanisms of tubulointerstitial injury in the kidney:final common pathways to end stage renal failure.Intern Med,2004,43(1):9-17.
6[5]Weigert C,Brodbeck K,Brosius FC 3rd,et al.Evidence for a novel TGF-betal-independent mechanism of fibronectin production in mesangial cells over expressing glucose transporters.Diabetes,2003,52:527-535.
7[7]Chen S,Jim B,Ziyadeh FN.Diabetic nephropathy and TGF-beta:transforming our view of glomerulosclerosis and fibrosis build up.Semin Nephrol,2003,23 (6):532-543.
8[8]Nicholas SB.Advances in pathogenetic mechanisms of diabetic nephropathy.Cell Mol Biol,2003,49(8):1319-1325.
9[9]Li JH,Zhu HJ,Huang XR,et al.Smad 7 inhibits fibrotic effect of TGF-beta on renal tubular epithelial cells by blocking smad 2 activaiton.J Am Soc Nephrol,2002,13(6):1464-1472.
10[10]Guh JY,Chuang TD,Chen HC,et al.Beta-hydroxybutyrate-induced growth inhibition and collagen production in HK-2 cells are dependent on TGF-beta and Smad 3.Kidney Int,2003,64(6):2041-2051.
