噻克硝唑对厌氧菌的体内外抗菌活性

The Study on Activities of Secnidazole against Anaerobic Bacteria in vitro and in vivo

目的:考察及评价噻克硝唑体内外对临床分离厌氧菌的抗菌活性。方法:采用琼脂二倍稀释法测定噻克硝唑、甲硝唑、替硝唑对临床分离的165株厌氧致病菌的MIC。采用体内保护实验测定噻克硝唑的体内抗菌活性。结果:(1)体外实验证明,噻克硝唑具有较强的抗菌活性,其对革兰氏阴性厌氧菌抗菌活性略强于对革兰氏阳性厌氧菌的抗菌活性。(2)噻克硝唑体内试验也呈现较强的抗厌氧菌作用,略强于甲硝唑、替硝唑。结论:噻克硝唑具有广谱抗厌氧菌作用。

Objective： To observe the anti- anaerobic activities of secnidazole. Methods： Minimal inhibitory concentration of secnidazole against 165 strains of anaerobic bacteria were detected by agar disk dilution assay, the vivo activities was established by mouse septicemia model by an intraperitoneai injection with anaerobic bacteria. Tinidazole and metronidazole were used as control drugs in this study. Results： MIC50 and MIC90 values of secnidazole,Tinidazole and metronidazole to 165 strains of anaerobic bacteria indicated the activity against Gram-negative anaerobic bacteria of secnidazole was slightly stronger than that of Gram-positive;The activities against anaerobic bacteria in vivo of secnidazole were stronger compaied with tinidazole and metronidazole respectively. Conclusion： Secnidazole were broad spectrum in anti-anaerobic activities.