非小细胞肺癌组织中P53和C-erbB-2蛋白的表达

Expression of P53 and C-erbB-2 in non-small cell lung cancer tissue

目的:检测非小细胞肺癌(NSCLC)组织中P53和C-erbB-2蛋白的表达。方法:采用免疫组织化学SP法检测30例癌旁正常组织和58例NSCLC组织中P53和C-erbB-2的表达,结合临床资料进行分析。结果:NSCLC组织中P53和C-erbB-2蛋白的阳性表达率分别为63.8%(37/58)和70.7%(41/58),均高于癌旁正常组织(13.3%(4/30),17.7%(5/30),P均<0.05)。NSCLC淋巴结转移组P53和C-erbB-2蛋白的阳性表达率分别为75.0%和80.0%,均高于无淋巴结转移组(38.9%,50.0%,P均<0.05)。NSCLC组织中P53和C-erbB-2的表达有关(χ2=5.32,P<0.05)。结论:NSCLC组织中P53和C-erbB-2蛋白高表达,2者可能共同参与了NSCLC的发生发展与转移。

Aim： To investigate the expression of P53 and C-erbB-2 in non-small cell lung cancer（NSCLC） tissue. Methods：The expressions of P53 and C-erbB-2 in 30 eases of normal tissue by the side of cancer and 58 eases of NSCLC tissue were detected by S-P immunohistoehemistry. Results：The positive expression rates of P53 and C-erbB-2 protein in NSCLC tissue were 63.8% and 70.7% , significantly higher than those in normal tissue （ 13.3 % , 17.7% ,P 〈 0.05 ） , re- spectively. In NSCLC tissue, the positive expression rates of P53 and C-erbB-2 protein in lymph node metastasis group were higher than those in the group without lymph node metastasis （ P 〈0.05 ）. The positive expression of P53 in NSCLC tissue was related with that of C-erbB-2. Conclusion ：P53 and C-erbB-2 in NSCLC tissue are highly expressed and they may in- volve in the development and lymph node metastasis of NSCLC.