摘要
在这研究,一不平常地二聚 d (GGGTGGGTGGGTGGGT )(S1 )G 四倍,有势力 nanomolar HIV-1 integrase 禁止者,被原子磁性的回声(NMR ) 检测。这结果被 electrospray 电离团 spectrometry (ESIMS ) 和圆形的二色性(CD ) 证实了。
In this research, an unusually dimeric G-quadruplex of d(GGGTGGGTGGGTGGGT) (SI), the potent nanomolar HIV-1 integrase inhibitor, was detected by nuclear magnetic resonance (NMR). This result has been confirmed by electrospray ionization mass spectrometry (ESI-MS) and circular dichroism (CD).
基金
the National Natural Science Foundation of China(No.20472009)
the Research Fund for the Doctoral Program of Higher Education.