高分辨快原子轰击质谱法及其在生物医学分析中的应用

High Resolution Fast Atom Bombardment Mass Spectrometry And Its Application In Biomedical Analysis

快原子轰击质谱经过十几年的发展，已成为分析极杜强、难挥发和热不稳定化合物囊常用的质谱方法，然而用快原子轰击质话进行精确质量测定的应用和研究开展还不很广泛．本文简要介绍了高分辨快原子轰击腐语法的方法和特点，并概述了高分辨快原子轰击质谱在生物医学分析几个主要方面（生物小分子、生物大分子、药物代谢产物和临床病理研究等）中的应用．

Since Barber and coworkers developed the method of Fast Atom Bombardment Mass Spectronetry(FABMS) in the early of 1980's,FABMS has become the most powerful mass spectrometric method for the analysis of polar,involatile and thermo-labile compounds. Considering the usefulness of high resolution FABMS in the evaluation of molecular structures,studies on accurate mass measurement by HRFABMS,and other applications of it have not been carried out extensively,in the present paper the experimental methods of HRFABMS,and the applications of HRFABMS in 4 aspects (small biomolecule, large biomolecule,polar products of drug metabolism and clinical pathological analysis) in the field of biomedical analysis were briefly described.