摘要
目的:研究熊果苷(Arbutin,Arb)抗炎作用及其作用机理。方法:观察Arb对佐剂性关节炎及噁唑酮引起的小鼠耳肿胀的影响;测定Arb对大鼠炎性组织PGE2含量及腹腔巨噬细胞释放ILB4的相对含量的影响。结果:Arb对福氏全佐剂诱发的大鼠原发性及继发性足肿胀具有抑制作用;对噁唑酮引起的小鼠两耳肿胀有抑制作用且使血中CD4+T细胞明显降低;可减少炎症组织PGE2水平及抑制大鼠腹腔巨噬细胞释放ILB4。结论:熊果苷的抗炎效果可能与抑制炎症介质PGE2及ILB4释放有关。
Objecive： To study the anti - inflammation effect and mechanism of Arbutin. Methods ：The effect of arbutin on adjuvant arthritis and on oxzolone induced mice ear swelling were investigated. PGE2 level in inflammatory tissue and ILB4 content released from peritoneal macrophage of rat treated with arbutin were determined. Results ：Arbutin could inhibit Freund＇s complete adjuvant induced rat primary and secondary foot swelling, and it could also inhibit oxazolone induced mice ear swelling and decrease CD4^＋ T cell in blood. Compared with control group, PGE2 level and ILB4 concentration in Arbutin treat group was remarkable lower. Conclusion ： The anti - inflammation effects of Arbutin maybe related with its inhibition of PGE2 and ILB4 release.
出处
《中华中医药学刊》
CAS
2008年第9期1933-1935,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省教育厅科研项目(20030879)
