中医心理治疗对复发性生殖器疱疹患者细胞免疫功能的影响

Effect of TCM Psychotherapy on Cell-Mediated Immune Response in Patients with Recrudescent GenitaI Herpes

目的:观察中医心理治疗在复发性生殖器疱疹(RGH)治疗中对患者T淋巴细胞亚群、细胞因子IL-2水平的影响作用。方法:研究采用随机配对双盲设计。将符合研究标准的复发性生殖器疱疹患者120例采用随机配对设计分为两组,甲组和乙组各60例。两组患者治疗前2周均检测外周血T淋巴细胞亚群、血清IL-2等免疫指标水平。所有受试对象均给予常规抗病毒西药治疗;而其中一组资料交给专门负责中医心理治疗的医生,由其负责联系资料中的患者,安排其每周接受一次中医心理治疗,疗程12周。治疗结束后2周再检测两组患者外周血T淋巴细胞亚群、血清IL-2等免疫指标水平。研究结束,将研究数据交专业统计员进行统计,对比分析,最后进行揭盲。结果:中医心理治疗组治疗后患者T淋巴细胞CD3+、CD4+细胞百分比及CD4+/CD8+比值升高,CD8+细胞百分比降低(P<0.001)血清IL-2水平升高(P<0.001);单纯西药治疗组治疗前后上述指标无明显变化。结论:中医心理治疗在复发性生殖器疱疹治疗中能起到改善、促进患者细胞免疫的作用。

Objective ： To observe the affect of TCM psychotherapy on the level of T - lymphocyte subsets and cell factor IL - 2 in patients with Recrudescent Genital Herpes （RGH）. Methods ： We conducted a double - blind, randomized paired study including 120 RGH patients who were dividedinto two groups, 60 subjects each group, For both groups, 2 weeks before the treatment ,we measured the level of peripheral blood T lymphocyte subsets and serum IL -2, All subjects were given regular antivirus western medicine, and the details on one of the two groups were sent to the doctors responsible for TCM psychotherapy,who contacted this group of patients and arranged them to receive weekly TCM psychotherapy for 12 weeks. Two weeks after the treatment, we measured the level of peripheral blood T lymphocyte subsets and serum IL - 2 again, After the study, we submited the data to the professional statistician for statistics, comparison and analysis. At last,we unblinded the patients, Results ：For the group receiving TCM psychotherapy, patients after treatment had increased percents of CD3^＋ and CD4^＋ cells （ T lymphocyte） and increased ratio of CD4^＋ /CD8 ^＋, decreased percent of CD8^＋ cells （ P 〈 0. 001 ）, and higher level of serum IL - 2 （ P 〈 0.001 ） ;for the group only receiving western medicine, the above indicators had no significant change before and after treatment, Conclusion ：TCM psychotherapy obviously improves and promotes the cell - mediated immune response in the treatment of RGH.